Narrow-band imaging for the detection of polyps in patients with serrated polyposis syndrome: a multicenter, randomized, back-to-back trial (2024)

Hazewinkel, Y., Tytgat, K. M. A. J., van Leerdam, M. E., Koornstra, J.-J., Bastiaansen, B. A., van Eeden, S., Fockens, P., & Dekker, E. (2015). Narrow-band imaging for the detection of polyps in patients with serrated polyposis syndrome: a multicenter, randomized, back-to-back trial. Gastrointestinal endoscopy, 81(3), 531-538. https://doi.org/10.1016/j.gie.2014.06.043

Hazewinkel, Yark ; Tytgat, Kristien M. A. J. ; van Leerdam, Monique E. et al. / Narrow-band imaging for the detection of polyps in patients with serrated polyposis syndrome : a multicenter, randomized, back-to-back trial. In: Gastrointestinal endoscopy. 2015 ; Vol. 81, No. 3. pp. 531-538.

@article{fb5ef89f5dd2450d927a0b08ec607a9d,

title = "Narrow-band imaging for the detection of polyps in patients with serrated polyposis syndrome: a multicenter, randomized, back-to-back trial",

abstract = "Background: Serrated polyposis syndrome (SPS) is characterized by the presence of multiple serrated polyps spread throughout the colon.Patients with SPS are considered to be at risk of colorectal cancer and are advised to undergo endoscopic surveillance. Narrow-band imaging (NBI) may improve the detection of polyps during these surveillance colonoscopies.Objective: To compare polyp miss rates between NBI and high-resolution white-light endoscopy (HR-WLE).Design: Multicenter, randomized, crossover study.Setting: Four tertiary referral institutions.Patients: A total of 52 patients with SPS undergoing surveillance colonoscopy.Intervention: All patients underwent back-to-back colonoscopies with HR-WLE and NBI in a randomized order.Main Outcome Measurements: Polyp miss rates of HR-WLE and NBI.Results: In the HR-WLE group, 116 polyps were detected during the first inspection. A second inspection with NBI added 47 polyps, resulting in an overall polyp miss rate of 29% with HR-WLE (95% confidence interval, 22-36). In the NBI group, a total of 128 polyps were detected during the first inspection. Subsequent inspection with HR-WLE added 32 polyps, resulting in an overall polyp miss rate of NBI of 20% (95% confidence interval, 15-27). Comparison of the overall polyp miss rates of HR-WLE and NBI showed no significant difference (P = .065).Limitations: Small sample size; second inspection was performed by the same endoscopist.Conclusions: The results of our study suggest that NBI does not reduce polyp miss rates in patients with SPS compared with HR-WLE. Further multinational studies with larger numbers of patients are warranted to verify these results.",

keywords = "HYPERPLASTIC POLYPOSIS, COLONOSCOPY SURVEILLANCE, COLORECTAL-CANCER, CLASSIFICATION, POLYPECTOMY, ENDOSCOPY, NEOPLASIA, SOCIETY, LESIONS, UPDATE",

author = "Yark Hazewinkel and Tytgat, {Kristien M. A. J.} and {van Leerdam}, {Monique E.} and Jan-Jacob Koornstra and Bastiaansen, {Barbara A.} and {van Eeden}, Susanne and Paul Fockens and Evelien Dekker",

year = "2015",

month = mar,

doi = "10.1016/j.gie.2014.06.043",

language = "English",

volume = "81",

pages = "531--538",

journal = "Gastrointestinal endoscopy",

issn = "0016-5107",

publisher = "MOSBY-ELSEVIER",

number = "3",

}

Hazewinkel, Y, Tytgat, KMAJ, van Leerdam, ME, Koornstra, J-J, Bastiaansen, BA, van Eeden, S, Fockens, P & Dekker, E 2015, 'Narrow-band imaging for the detection of polyps in patients with serrated polyposis syndrome: a multicenter, randomized, back-to-back trial', Gastrointestinal endoscopy, vol. 81, no. 3, pp. 531-538. https://doi.org/10.1016/j.gie.2014.06.043

Narrow-band imaging for the detection of polyps in patients with serrated polyposis syndrome: a multicenter, randomized, back-to-back trial. / Hazewinkel, Yark; Tytgat, Kristien M. A. J.; van Leerdam, Monique E. et al.
In: Gastrointestinal endoscopy, Vol. 81, No. 3, 03.2015, p. 531-538.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Narrow-band imaging for the detection of polyps in patients with serrated polyposis syndrome

T2 - a multicenter, randomized, back-to-back trial

AU - Hazewinkel, Yark

AU - Tytgat, Kristien M. A. J.

AU - van Leerdam, Monique E.

AU - Koornstra, Jan-Jacob

AU - Bastiaansen, Barbara A.

AU - van Eeden, Susanne

AU - Fockens, Paul

AU - Dekker, Evelien

PY - 2015/3

Y1 - 2015/3

N2 - Background: Serrated polyposis syndrome (SPS) is characterized by the presence of multiple serrated polyps spread throughout the colon.Patients with SPS are considered to be at risk of colorectal cancer and are advised to undergo endoscopic surveillance. Narrow-band imaging (NBI) may improve the detection of polyps during these surveillance colonoscopies.Objective: To compare polyp miss rates between NBI and high-resolution white-light endoscopy (HR-WLE).Design: Multicenter, randomized, crossover study.Setting: Four tertiary referral institutions.Patients: A total of 52 patients with SPS undergoing surveillance colonoscopy.Intervention: All patients underwent back-to-back colonoscopies with HR-WLE and NBI in a randomized order.Main Outcome Measurements: Polyp miss rates of HR-WLE and NBI.Results: In the HR-WLE group, 116 polyps were detected during the first inspection. A second inspection with NBI added 47 polyps, resulting in an overall polyp miss rate of 29% with HR-WLE (95% confidence interval, 22-36). In the NBI group, a total of 128 polyps were detected during the first inspection. Subsequent inspection with HR-WLE added 32 polyps, resulting in an overall polyp miss rate of NBI of 20% (95% confidence interval, 15-27). Comparison of the overall polyp miss rates of HR-WLE and NBI showed no significant difference (P = .065).Limitations: Small sample size; second inspection was performed by the same endoscopist.Conclusions: The results of our study suggest that NBI does not reduce polyp miss rates in patients with SPS compared with HR-WLE. Further multinational studies with larger numbers of patients are warranted to verify these results.

AB - Background: Serrated polyposis syndrome (SPS) is characterized by the presence of multiple serrated polyps spread throughout the colon.Patients with SPS are considered to be at risk of colorectal cancer and are advised to undergo endoscopic surveillance. Narrow-band imaging (NBI) may improve the detection of polyps during these surveillance colonoscopies.Objective: To compare polyp miss rates between NBI and high-resolution white-light endoscopy (HR-WLE).Design: Multicenter, randomized, crossover study.Setting: Four tertiary referral institutions.Patients: A total of 52 patients with SPS undergoing surveillance colonoscopy.Intervention: All patients underwent back-to-back colonoscopies with HR-WLE and NBI in a randomized order.Main Outcome Measurements: Polyp miss rates of HR-WLE and NBI.Results: In the HR-WLE group, 116 polyps were detected during the first inspection. A second inspection with NBI added 47 polyps, resulting in an overall polyp miss rate of 29% with HR-WLE (95% confidence interval, 22-36). In the NBI group, a total of 128 polyps were detected during the first inspection. Subsequent inspection with HR-WLE added 32 polyps, resulting in an overall polyp miss rate of NBI of 20% (95% confidence interval, 15-27). Comparison of the overall polyp miss rates of HR-WLE and NBI showed no significant difference (P = .065).Limitations: Small sample size; second inspection was performed by the same endoscopist.Conclusions: The results of our study suggest that NBI does not reduce polyp miss rates in patients with SPS compared with HR-WLE. Further multinational studies with larger numbers of patients are warranted to verify these results.

KW - HYPERPLASTIC POLYPOSIS

KW - COLONOSCOPY SURVEILLANCE

KW - COLORECTAL-CANCER

KW - CLASSIFICATION

KW - POLYPECTOMY

KW - ENDOSCOPY

KW - NEOPLASIA

KW - SOCIETY

KW - LESIONS

KW - UPDATE

U2 - 10.1016/j.gie.2014.06.043

DO - 10.1016/j.gie.2014.06.043

M3 - Article

SN - 0016-5107

VL - 81

SP - 531

EP - 538

JO - Gastrointestinal endoscopy

JF - Gastrointestinal endoscopy

IS - 3

ER -

Hazewinkel Y, Tytgat KMAJ, van Leerdam ME, Koornstra JJ, Bastiaansen BA, van Eeden S et al. Narrow-band imaging for the detection of polyps in patients with serrated polyposis syndrome: a multicenter, randomized, back-to-back trial. Gastrointestinal endoscopy. 2015 Mar;81(3):531-538. doi: 10.1016/j.gie.2014.06.043